EQUAL
EQUAL Training Course
and Conference Amsterdam (The Netherlands):
"Lifting your DNA skills
to a higher level"
"Hot topics in DNA diagnostics"
A three days meeting which includes practical activities
in the laboratory (revision to the EQUAL-qual
programme) and lectures on:
Scientific programme on genetics in cancer, quality
control in DNA diagnostics and pharmacogenetics
Practical course on quality issues in DNA diagnostics
|
Amsterdam,
the Venice of the North |
| Venue | Scientific session and practical activities Academic Medical Centre |
|
| How to get there | Equal participants will receive all information. | |
| Date | December 1st, 2nd and 3rd, 2005 |
|
| Coordinators | Scientific coordinator: |
Prof Dr A Sturk, Department of Clinical Chemistry, Academic Medical Centre |
| EQUAL committee: the Netherlands |
J. Danneberg; M. Goorhuis; A. Martens | |
| Organizers: | C.M. Cobbaert; A. Martens; R.H.N. van Schaik; J.Prins |
|
| Local organizers: | A.K. Stroobants, S. van Wilpe | |
| General Information of the Training Course | The scientific programme on December 1st includes lectures
on clinical molecular diagnostics addressed to hereditary colon/breast
cancer, quality control, and pharmacogenetics. The practical course on
December 2nd and 3rd will include 3 topics: 1. Isolation methods for DNA and the impact on its quality, 2. DNA multiplication procedures, 3. Information on DNA quality issues and primer design via the web. |
|
| Scientific topics | Several types of cancer have now been demonstrated to have
a genetic basis, albeit in a subpopulation of those patients. The main
examples with major progress in this field are the breast cancers and
the intestinal cancers. The present status of those fields, e.g. the
genes involved, their functions if known, their prognostic values, as
well as possible treatment considerations will be discussed.
DNA-based diagnostics is on the one hand just a laboratory matter similar to all other procedures, but with on the other hand several pitfalls specific to that part of the laboratory activities. Pre-analytical issues including sample preparation, multiplication and potential contamination, analytical issues and careful interpretation and handling of the results are of much more concern than generally necessary. The chain of such quality issues, including internal and external quality control, will be discussed. Pharmacogenetics is a blooming issue in the scientific literature,
with major progress in the insight in the usefulness of DNA profiling,
as well as sobering thoughts that not all can be predicted based upon
such a profile. These topics will be addressed. |
|
| Practical activities | The main aim of the practical part of the EQUAL training
course in Amsterdam, totalling 12 hours of intense activities in three
subgroups, is to provide the participants with insight in the impact
of the DNA handling on their DNA diagnostics results, to show them various
methods of DNA multiplication (including major equipment options demonstrated
by the main companies in this field) and to teach them how to obtain
useful information via the web. The three subgroups will all perform
the whole programme, but in a circulating manner. After participation in this DNA course the acquired skills of the participants will be assessed by their retesting regular EQUAL samples. |
|
| Scientific Programme | ||
All participants: |
||
| Thursday December 1st 2005 | ||
9.15 - 9.55
|
Registration and coffee | |
9.55 - 10.00
|
Opening by prof dr A. Sturk | |
10.00 -10.45
|
Hereditary breast/ovarian cancer: the experience of 10 years of molecular diagnostics dr A.M.W. van den Ouweland, Department of Clinical Genetics, Erasmus Medical Centre, Rotterdam, the Netherlands |
|
10.45 - 11.30
|
Hereditary colon cancer Dr J.C.H. Hardwick, Department of Gastroenterology, Academic Medical Centre, Amsterdam the Netherlands |
|
11.30 - 12.00
|
Coffee break | |
12.00 - 12.45
|
Molecular testing: the quality issues R. Goodall, BSC MSc, Department of Clinical Biochemistry, Lewis Laboratory, Southmead Hospital, Bristol, United Kingdom |
|
12.45 - 13.45
|
Lunch break | |
13.45 - 15.30
|
How to establish and maintain the quality of genetic testing? prof dr E.M.C. Dequeker, Department of Human Genetics, University of Leuven, Leuven, Belgium |
|
15.30 - 15.00
|
Tea break | |
15.00 -15.45
|
Pharmacogenetics and psychoactive drugs: CYP2D6/CYP2C19 and amitriptyline as a model for individualizing therapy W. Steimer MD, Institute for Clinical Chemistry and Pathobiochemistry, Munich University of Technology, Munich, Germany |
|
15.45 - 16.30
|
Clinical applications of pharmacogenetics dr M. Linder, Department of Pathology and Laboratory Medicine, Pharmacogenetics Diagnostics Laboratory, Louisville, USA |
|
16.30 - 18.00
|
Drinks | |
19.00
|
Social programme for EQUAL participants | |
| EQUAL participants only: | ||
| Friday December 2nd 2005 | ||
9.30 -17.30
|
Practical activities | |
18.00
|
Social programme | |
| Saturday December 3rd 2005 | ||
9.30 -13.30
|
Practical activities | |
| Registration Form (no registration fee) |
Do you want to register as an EQUAL-qual participant? click
here Do you want to register as a non-EQUAL participant? click here |
|
| Contact us | Local organizing committee: Dr. A.K. Stroobants Dr. S. van Wilpe
|
EQUAL committee: A. Martens |
| Website
by dtp studio oldenburg |